• br Asthma The chronic airway inflammatory disease asthma is

  2024-12-20

  

  Asthma The chronic airway inflammatory disease PyBOP is associated with enhanced levels of exhaled NO generated by iNOS in the airway epithelium [12]. In asthmatic patients local and systemic changes in iNOS, peroxynitrite, arginase, ADMA and arginine levels have been observed and are associated

• br Introduction Natural antioxidants in vegetables

  2024-12-20

  

  Introduction Natural antioxidants, in vegetables, have gained the attention of both researchers and consumers. Vegetable amaranth (Amaranthus tricolor) is a good source of minerals, vitamins, phenolics, and carotenoids; it also contains betalains, a nitrogen containing group of natural pigments,

• Given that neither case is derived from multiplex

  2024-12-20

  

  Given that neither case is derived from multiplex genotyping mice with affected individuals, principles of Mendelian segregation cannot be applied to implicate the T201S mutation in causing familial CJD. In addition, like many rare gene variants, it is not possible to apply practice guidelines such

• The Nagoya Heart Study enrolled patients with

  2024-12-20

  

  The Nagoya Heart Study enrolled patients with hypertension and type 2 diabetes or impaired ion channels tolerance (12). Patients were randomized to valsartan- or amlodipine-based regimens with a BP target of ≤130/80 mmHg. The primary outcome was a composite of sudden cardiac death, myocardial infar

• br Acknowledgments This work was

  2024-12-20

  

  Acknowledgments This work was supported by a grant of the Romanian National Authority for Scientific Research, CNCS – UEFISCDI, project no. PN-II-ID-PCE-2011-3-0571, awarded to F.A.M. D.V.N. was co-financed from the European Social Fund through Sectorial Operational Program Human Resources Develo

• The amino acids evaluated in this study

  2024-12-20

  

  The amino acids evaluated in this study represent proteinogenic (amino acids that are applied in the genetic code) or even essential ones (amino acids that cannot be synthesised by the organism and need to be taken up by nutrition). Tryptophan, phenylalanine, tyrosine, isoleucine, threonine and vali

• Although several ARIs have reached various

  2024-12-20

  

  Although several ARIs have reached various phases of clinical experimentation however most of them have been withdrawn either due to an insufficient bioavailability, their poor efficacy or adverse side effects. Currently Epalrestat is in clinical use for the treatment of diabetic neuropathy. The sid

• As one of emerging high throughout methods metabolomics

  2024-12-20

  

  As one of emerging high-throughout methods, metabolomics detects metabolites which are ultimate response of biological systems to environmental changes [14]. Metabolomics uncovers metabolic alteration at the systems level. Comparison of global metabolic profiling reflects some unidentified biologica

• br Downstream signalling of AKT

  2024-12-20

  

  Downstream signalling of AKT A consensus phosphorylation motif has been described for AKT substrates: R-X-R-X-X-S/T-B where X represents any amino Urolithin A receptor and B represents bulky hydrophobic residues (Alessi, Caudwell, Andjelkovic, Hemmings, & Cohen, 1996). Numerous AKT substrates ha

• br Acknowledgments This work was supported by Grant in

  2024-12-20

  

  Acknowledgments This work was supported by Grant-in-aid for Scientific Research (S) (20229008) (to T.K.), Targeted Proteins Research Program (to T.K.), the Global COE Research Program (to T.K.) and Translational Systems Biology and Medicine Initiative (to T.K.) from the Ministry of Education, Cul

• Phosphodiesterase inhibition increases the intracellular lev

  2024-12-20

  

  Phosphodiesterase inhibition increases the intracellular levels of cAMP to restore spontaneous contraction (Essayan, 2001, Qi and Kwan, 1996), acting downstream of adenylyl cyclase. Therefore, cardiac arrest induced by decreased intracellular cAMP levels could be reversed by phosphodiesterase inhibi

• Salivary amylase activity was not significantly different be

  2024-12-20

  

  Salivary α-amylase activity was not significantly different between bitches with pyometra and healthy bitches, and there were no significant changes after ovariohysterectomy, similar to chromogranin A (Jitpean et al., 2015). Therefore, it is postulated that the SAM axis is not activated in bitches w

• During years research efforts at Los Alamos National Laborat

  2024-12-19

  

  During 2002–2004years research efforts at Los Alamos National Laboratory (LANL) focused on constructing a quantum computer based on regular arrays build from neutral radical molecules possessing one single unpaired 2-Phenyl-2-(1-piperidinyl)propane spin. The idea was built on the ability to manipula

• The small fishers with little

  2024-12-19

  

  The small fishers with little or no quota who remained relied on quota leasing arrangements to continue their fishing operations. Such arrangements had relatively high transaction costs and by early 2000 it appeared that the demise of the small fisher was imminent [2]. The introduction in 2001 of t

• In order to improve the methodology of the synthesis of

  2024-12-19

  

  In order to improve the methodology of the synthesis of steroidal derivatives, our goal was the investigation of aza-Michael addition of different N-nucleophiles to 16-dehydropregnenolone in the presence of [DBU][OAc] as catalyst and reaction medium. Michael addition of electron deficient steroidal

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