• br It s that time of year

  2019-06-29

  

  It\'s that time of year again when we ask readers to submit photographs for our annual Highlights photography competition. We are looking for striking images that arrest our attention about any topic in medicine, from global health to clinical medicine, from the individual person to populations.

• br Materials and methods br

  2019-06-29

  

  Materials and methods Results and discussion ABT-737 is a BH3-mimetic targeting Bcl-2, Bcl-XL and Bcl-W. The aim of the experiments was to test whether inhibition of Bcl-2 and Bcl-XL using ABT-737 can eradicate the CD34+/CD38− AML cell population. Bone marrow MNCs from patients (Table 1) were

• Introduction Acute myeloid leukemia AML

  2019-06-29

  

  Introduction Acute myeloid leukemia (AML) is a rare disease afflicting annually 3–4 persons per 100,000 individuals. With a median age at diagnosis of 67 years, this disease is far more common in the elderly [1]. In this age group, AML has a particularly dismal outcome with less than 5% of the pati

• br Conclusions br Acknowledgements This

  2019-06-28

  

  Conclusions Acknowledgements This work was supported by Bloodwise, the International Myeloma Foundation and a Marie Curie Career Integration Grant from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° [294160]. The osteoblast in normal bone physiology

• After the RFCA neither sustained VT

  2019-06-28

  

  After the RFCA, neither sustained VT nor the VPCs that triggered the VT were recorded. The patient was fitted with a WCD (LifeVest, Zoll, Pittsburgh, PA, USA) on the third day post-ablation, and sotalol 80mg a day was started. He was discharged from the coronary care unit the following day. During c

• PQ 401 weight br A hallmark of the past decade has

  2019-06-28

  

  A hallmark of the past decade has been the remarkable progress made in reducing maternal and child mortality, an achievement credited in some measure to the Millennium Development Goals. The reduction in child deaths from an estimated 12·7 million under-5 deaths in 1990 to fewer than 6 million dea

• Introduction Atrial fibrillation AF is a

  2019-06-28

  

  Introduction Atrial fibrillation (AF) is a common cardiac arrhythmia that becomes more prevalent with age [1] and is associated with an increased long-term risk of stroke, papain inhibitor failure, and all-cause mortality [2]. Since Einthoven recorded the electrograms in 1906 [3], AF has widely be

• In the present study we found that stathmin

  2019-06-28

  

  In the present study, we found that stathmin was significantly down-regulated upon treatment with a combination of Zol and gefitinib. The down-regulation of stathmin, which was not detected by 2-D DIGE after treatment with either agent alone, was considered to be attributable to cooperative effect o

• After overdrive pacing excitation that is one lap

  2019-06-28

  

  After overdrive pacing, excitation that is one lap behind (the second beat after the stimulus) is caused by several mechanisms. One is the prolonged conduction time that is longer than the TCL due to a long conduction pathway and/or slow conduction. The other is the dual-loop reentry [12]. The excit

• br Case An year old man with

  2019-06-28

  

  Case 1 An 81-year-old man with no history of AdipoRon disease was admitted to our hospital for the treatment of recurrent episodes of syncope after drinking. He experienced the first episode at age 75. On admission, his blood pressure (BP) was 144/81mmHg and the heart rate (HR) was 56beats/min.

• PF-670462 what br Discussion There were recurrences out of p

  2019-06-28

  

  Discussion There were 2 recurrences (8.3%¸ 2 out of 24 patients), 1 of which occurred immediately following the procedure. In this patient, SVT was not induced with programmed atrial or ventricular stimulations after the ablation of accessory pathway. Ventriculoatrial conduction was through the A

• La cr nica es en las obras de N

  2019-06-28

  

  La crónica es en las obras de Nájera, además de profusa, el género que imprimió mayor libertad creativa al contenido de sus temas, razón por la que sus múltiples intereses se vieron arropados más confortablemente en ella. La crónica de , otro de sus heterónimos más conocidos, fue entre otras cosas u

• Introduction Friedenstein was the first person

  2019-06-27

  

  Introduction Friedenstein was the first person to describe the isolation of clonogenic, proliferating fibroblastic MSCs from rat bone marrow (BM). And they showed that colony-forming unit fibroblasts (CFU-Fs) derived stromal SMI-4a can serve as feeder layers for the culture of heamatopoietic stem

• To date over mutations in KCNQ have

  2019-06-27

  

  To date, over 250 mutations in KCNQ1 have been found to be linked to LQT1 [34] and new LQT1 causing mutations continue to be identified. The vast majority of KCNQ1 mutations are single nucleotide substitutions (missense) or small insertion/deletions that localize to the S1-S6 transmembrane domains [

• Since antithrombotic therapy for patients with AF is

  2019-06-27

  

  Since antithrombotic therapy for patients with AF is rapidly changing with the increasing use of dabigatran, rivaroxaban, and apixaban, some of the primary issues that will influence the future revision of various guidelines (HRS [Heart Rhythm Society], ESC [European Society of Cardiology], ACC [Ame

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