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EPAC activation in VSMCs and ECs reverses several processes
2020-02-05
EPAC activation in VSMCs and ECs reverses several processes involved in the development of in-stent restenosis. Of particular relevance is the ability of EPAC1 to induce SOCS3 gene expression, as SOCS3 exerts multiple protective effects in both cell types, while immunohistochemical studies have show
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br Materials and methods br Results br Discussion COX
2020-02-05
Materials and methods Results Discussion COX-2-mediated production of PGE2 is involved in cell growth and metastasis of many cancers. Previous studies indicated that COX-2 was overexpressed in many cancer tissues and that PGE2 increased cancer cell growth, a process that could be suppressed
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Introduction With an annual world production of around milli
2020-02-05
Introduction With an annual world production of around 750 million tons, wheat is grown on more agricultural area than any other food crop and is the main source of plant protein in human nutrition [1,2]. Wheat is composed of 8–15% protein, from which 85–90% is gluten [3]. The unique viscoelastic a
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Immune Response and Immune Evasion Up to of
2020-02-05
Immune Response and Immune Evasion Up to 10% of the host ixazomib australia are infected with EBV during acute infectious mononucleosis. Most of these cells are effectively cleared by the immune system, but some downregulate viral gene expression and differentiate into safety in the resting memory
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The preferences for source of FAs for DGAT and
2020-02-05
The preferences for source of FAs for DGAT1 and DGAT2 are related to their membrane topologies, subcellular locations, interactions with other proteins or organelles (discussed in the former section), and their differential expression, substrate specificities, and enzyme kinetics. According to UniPr
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Previously we showed that MS a combined extract
2020-02-04
Previously, we showed that MS-10, a combined extract of Cirsium japonicum var. Maackii (Maxim.) Matsum. (Korean milk thistle) and Thymus vulgaris L., increases the efficiency of estrogen in the estrogen-deficient state by activating the estrogen receptor (ER). MS-10 increased bone mineral density (B
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Kasugamycin hydrochloride synthesis Given the fact that most
2020-02-04
Given the fact that most criticism on genetic association studies is the lack of replicability (Hirschhorn, Lohmueller, Byrne, & Hirschhorn, 2002), the aim of the present study is to investigate the influence of the DBH polymorphism rs1611115 (C-970T) on RD in two independent samples of healthy part
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Although many neurotransmitters e g
2020-02-04
Although many neurotransmitters (e.g., catecholamines, serotonin, and excitatory/inhibitory amino acids) have been implicated in the modulation of anxiety-like responses (Carobrez et al., 2001, Molchanov and Guimaraes, 2002, Vianna et al., 2001), the so-called atypical neurotransmitters, endocannabi
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br The LSCP model and its properties In this section
2020-02-04
The LSCP model and its properties In this section, we first introduce the LSCP model in Section 2.1. Some examples of the model are presented in Section 2.2 and basic properties of the model are presented in Section 2.3. Finally, Section 2.4 introduces finite dimensional approximations necessary
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Ginsenoside Rd sale By using the C elegans Matrisome Annotat
2020-02-04
By using the C. elegans Matrisome Annotator tool, we found substantial enrichment for matrisome Ginsenoside Rd sale in these data sets. Thus, re-analyzing -omic datasets with the C. elegans Matrisome Annotator tool may be useful to generate novel hypotheses about the role of the C. elegans matrisom
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So far several important flovonoids and polyphenoilc compoun
2020-02-04
So far, several important flovonoids and polyphenoilc compounds were subjected to various human studies regarding their potential therapeutic and adverse effects (Ide et al., 2014; Turner et al., 2015; Witte et al., 2014) (Table 1). Resveratrol (trans-3,4, 5-trihydroxystilbene) is widespread stilbe
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For this reason downstream components of the inflammatory pa
2020-02-04
For this reason, downstream components of the inflammatory pathway have been investigated in the search for alternative targets. Targeting such downstream elements might result in safer and more tolerable analgesics. PGE mediates its effects through binding to four G-protein-coupled receptors (EP1-4
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I bungarotoxin competes with ACh
2020-02-04
[125I] α-bungarotoxin competes with ACh, an endogenous activator of α7-nACh receptors by binding to the ACh binding site on the receptor (Albuquerque et al., 2009). For this reason, the effect of curcumin was investigated on the specific binding of [125I] α-bungarotoxin. Saturation curves for the bi
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Although enantioselective accumulation of metalaxyl in organ
2020-02-04
Although enantioselective accumulation of metalaxyl in organisms is an integrated outcome of bio-process including absorption, transportation, and transformation, it is observed in our study that catalysis of CYP450 may lead to the enantioselective accumulation of metalaxyl. However, the mechanisms
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Preliminary studies evidenced the presence of CRFr in
2020-02-04
Preliminary studies evidenced the presence of CRFr in gamma-aminobutyric acid-ergic (GABAergic) neurons of the hippocampus (Yan et al., 1998). In fact, in this Semaxanib area, CRF inhibits glutamate release through CRF1r (Bagosi et al., 2015), leading to a decrease in the GABA concentration in the
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