• Treatment related adverse events have been

  2020-08-10

  

  Treatment-related adverse events have been a serious issue in clinical application. Severe toxicity has been reported in clinical trials using antibody blockade of CSF-1R (20 mg/kg), PD-1, and CTLA-4.29, 30, 31 However, apparent side effects were not observed in our study with PLX3397 treatment alon

• br Experimental Procedures br Author Contributions br Acknow

  2020-08-10

  

  Experimental Procedures Author Contributions Acknowledgments We thank the Mouse Modeling, Integrated Microscopy, and FACS Facilities of IGB-CNR, Naples. Dr. Laura Pisapia is acknowledged for flow cytometry analyses. We are grateful to Prof. Chris Ponting and George A. Calin for insightful s

• Interest in the PGE EP pathway

  2020-08-10

  

  Interest in the PGE2/EP4 pathway is increasing given its diverse capability of regulating central nervous system activity [13]. EP4 has a protective function by reducing cerebral injury and improving functional outcome after stroke [14], and in suppressing geldanamycin inflammation [15]. The EP4 re

• The synthetic routes to the substrates based on

  2020-08-10

  

  The synthetic routes to the substrates based on the 2,3-dihydroxynaphthalene and 6,7-dibromo-2,3-dihydroxynaphthalene cores are depicted in Scheme 3. A Michael-type glycosylation of 2,3-dihydroxynaphthalene 16a gave the acetylated sugar 17a which was deprotected giving the required β-glucosidase sub

• The enantiomeric ratio ER of chiral compounds

  2020-08-10

  

  The enantiomeric ratio (ER) of chiral compounds accumulated in organisms has been found to be different among species (Borga and Bidleman, 2005, Harner et al., 1999, Warner et al., 2005, Wiberg et al., 2000), indicating enantioselective accumulation of chiral compounds are species-specific. The ER o

• Altogether these data suggested that GlmU might be involved

  2020-08-08

  

  Altogether these data suggested that GlmU might be involved in the M. smegmatis biofilm mediated defence mechanisms. GlmU belongs to a metabolic pathway leading to UDP-GlcNAc from fructose-1-phosphate involved in the biosynthesis of peptidoglycan and lipopolysaccharide (Fig. 8). Recently, we demonst

• br Conclusion br Declaration of interest br

  2020-08-08

  

  Conclusion Declaration of interest Introduction Glyphosate [N-(phosphonomethyl)glycine] is the main active ingredient in one of the most widely used herbicides in the world. The commercially used concentrations of glyphosate range from 1% for domestic use to 41% for conventional agricultura

• br Disclosure br Acknowledgments This study

  2020-08-08

  

  Disclosure Acknowledgments This study was partly supported by a Grant-in-Aid for Scientific Research B (22390391539) from JSPS, Japan. Introduction Taenia multiceps is a taeniid cestode with an adult stage that lives in the small intestine of dogs and other canids. The larval stage (Coenur

• br Other functions of SERPINB

  2020-08-07

  

  Other functions of SERPINB1 On one hand, we have recently shown that in bovine corneal epithelium LEI increases its expression early after injury and returns to basal levels immediately after wound closure [71]. This increase is blocked by N-acetylcysteine, suggesting that production of reactive

• An NDE of a predicted molecular mass

  2020-08-07

  

  An NDE3 of a predicted molecular mass of ∼55kDa has been localized both in the mitochondria and in the cytosol of N. crassa and its sequence shows no typical features of a mitochondrial cleavable targeting sequence (Carneiro et al. 2007). This enzyme has been proven to be anchored in the inner mitoc

• Additionally we observed the potential synergy of XJD and ge

  2020-08-06

  

  Additionally, we observed the potential synergy of XJD and gefitinib. As a first generation EGFR-TKI and first-line treatment for some NSCLC patients, gefitinib was reported to inhibit growth, metastasis, and angiogenesis, and significantly prolong survival time for patients with tumors containing a

• Elastin is a highly elastic protein found in

  2020-08-06

  

  Elastin is a highly elastic protein found in connective tissues including skin, lung, and arteries and helps in maintaining tissue configuration after stretch or recoil (Daamen et al., 2007, Debelle and Alix, 1999). Overexposure to UV irradiation and oxidative damage up regulate the expression of el

• In the present work we have investigated

  2020-08-06

  

  In the present work, we have investigated the reactivity of N-aryl-N′-hydroxyguanidines 1a–d (see Scheme 1 for structures) with the water-soluble Cu(II) complex 8. Using EPR and UV–Visible spectroscopy, we have shown that the studied N-aryl-N′-hydroxyguanidines 1a–d can bind and transfer electrons t

• Phenytoin sodium Induction of DNA double stranded breaks DSB

  2020-08-06

  

  Induction of DNA double stranded breaks (DSBs) by radiation is considered an effective approach for the treatment of cancer (Jeggo and Lobrich, 2007, McKinnon and Caldecott, 2007). Both radiation and a wide range of anticancer agents act by the induction of DSB in cancer cells, thereby causing cell

• Remarkably the role of Wolbachia during filarial development

  2020-08-06

  

  Remarkably, the role of Wolbachia during filarial development, molting and embryogenesis is similar to the roles attributed to these proteases in filarial development (Lustigman et al., 1992, Lustigman et al., 1996, Lustigman et al., 2004, Tort et al., 1999, Guiliano et al., 2004, Ford et al., 2009)

15088 records 739/1006 page Previous Next First page 上5页 736737738739740 下5页 Last page