• Although the role of mossy fiber sprouting in

  2023-10-18

  

  Although the role of mossy fiber sprouting in epileptogenesis has been challenged (Elmer et al., 1997, Nissinen et al., 2001), in addition to astrogliosis, mossy fiber sprouting is one of the characteristic histopathological findings in TLE (Kharatishvili et al., 2006, Pitkanen et al., 2007, Represa

• br Dihydrotestosterone in adult fish and frogs

  2023-10-18

  

  Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance

• On another hand pyrazoles are widely found as the

  2023-10-18

  

  On another hand, pyrazoles, are widely found as the core structure in a large variety of compounds of great biological and pharmaceutical value exhibiting anti-HCV [11], antitumor [12], cytotoxic[13], and antioxidant activities [14]. Finally, 1,2,3-triazoles have attracted the interest of medicinal

• Along with the improvement of the cadmium

  2023-10-18

  

  Along with the improvement of the cadmium transport from roots to aerial tissues, as is required for phytoremediation, over-expression of PtoHMA5 also led to the excessive accumulation of cadmium in leaves that was harmful to plant growth and physiological performance. Thus, detoxification of the he

• br Perspective AA LA and other

  2023-10-18

  

  Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path

• br Introduction Rhamdia quelen jundi Silurifomes

  2023-10-18

  

  Introduction Rhamdia quelen (jundiá, Silurifomes, Heptapteridae) is a neotropical catfish widely distributed in Central and South America (Silfvergrip, 1996). This species shows high potential for the aquaculture industry, due to an elevated growth rate, good carcass yield, and easy reproduction

• The isoelectric point of CL ARG

  2023-10-18

  

  The isoelectric point of CL-ARG was determined by native IEF at a Mexiletine HCl gradient in the range (3–10) using standard protein markers with known isoelectric points. Native IEF reveals the presence of only one major band for CL-ARG with a slightly neutral-basic pI value of about 7.7. The calc

• br Secreted enzymes Only two secreted S

  2023-10-18

  

  Secreted enzymes Only two secreted S. aureus enzymes reportedly induce apoptosis, namely, staphylococcal staphopain B (SspB) and coagulase. SspB selectively cleaved CD11b/CD18 integrin and induced an apoptosis-like cell death in neutrophils and monocytes (Smagur et al., 2009). Neutrophils or mono

• The subnuclear localizations of redox regulators is also

  2023-10-17

  

  The subnuclear localizations of redox regulators is also largely unknown. The potential role of thiol reductases as transcription regulators or DNA repair molecules may suggest an association to DNA. In this way, the presence of a zinc finger domain potentially involved in protein/DNA interactions o

• br Acknowledgments The authors thank Claudia

  2023-10-17

  

  Acknowledgments The authors thank Claudia Wittrock for her excellent technical assistance. The work was supported by grants of the Deutsche Forschungsgemeinschaft (SFB974 TP B05) and of the Anton-Betz-Stiftung to N.K. A.M. is an associate member of the iBrain graduate school at the University of

• br Functions essentially consisting in transport of substrat

  2023-10-17

  

  Functions essentially consisting in transport of substrates across plasma membranes Direct activation of neurotransmitter transporters elicits responses in neurons As previously mentioned (Section 2.1), nerve terminals handling classical transmitters possess transporters able to (re)capture se

• The AHR potentially enhances IDO expression

  2023-10-17

  

  The AHR potentially enhances IDO-expression, possibly via crosstalk with several inflammatory signaling pathways (shown by now for IL6 and ‘signal transducer and activator of transcription’ (STAT) 3, and for NFκB, toll like receptor-pathways) [56,59,60]. IDO metabolizes Trp to kynurenines, which are

• However although in vitro studies in heterologous systems

  2023-10-17

  

  However, although in vitro studies in heterologous systems have provided very important indications of potential novel pharmacology, the studies with endogenous receptors in native tissues are essential to provide evidence for GPCR heteromerization in vivo and to confirm its physiological relevance.

• Adenosine receptors are proposed to play

  2023-10-17

  

  Adenosine receptors are proposed to play proangiogenic role in vascular and immune Sarpogrelate hydrochloride within microenvironment of hypoxic tissues to maintain tissue oxygenation in chronic ischemic condition [9]. Adenosine also stimulates the production of angiopoetin-1, VEGF and Interleukin-6

• Moreover our results indicate that ADP is

  2023-10-17

  

  Moreover, our results indicate that ADP is by far a better phosphate donor than AMP (Table 2). Yet, the bindings of AMP and ATP are mutually exclusive, whereas the bindings of ADP and ATP are additive (Fig. 7). The multiplicity of the phosphate donors in the TgAK reaction (Tables 1 & 2), suggests th

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