• Circulating adrenal derived stress hormones epinephrine and

  2024-02-02

  

  Circulating adrenal-derived stress hormones, epinephrine and corticosterone mediate their tissue effects through adrenergic (AR; α and β) and glucocorticoid (GR) receptors. AR are widely distributed throughout the body and although epinephrine is a prototypical agonist for all types of AR, the selec

• Our results showed that oral administration of cordycepin in

  2024-02-02

  

  Our results showed that oral administration of cordycepin, in the concentrations of 5 and 10mg/kg for 3weeks, exerted no influence on body weight and hippocampus weight in mice. Although some reports have pointed out that cordycepin had toxic effects because it may be potential for inducing cell dea

• Streptomycetes are a group of filamentous Gram positive

  2024-02-02

  

  Streptomycetes are a group of filamentous Gram-positive, soil-inhabiting bacteria which have captured enormous screening interest because of their ability to produce and secrete a variety of Bradykinin acetate and extracellular proteins [7]. Among the diverse antibiotics produced by Streptomycetes a

• Multiple ASD susceptibility genes converge on

  2024-02-02

  

  Multiple ASD susceptibility genes converge on cellular pathways that intersect at the postsynaptic site of glutamatergic synapses (Bourgeron, 2015; Peca & Feng, 2012), the development and maturation of synaptic contacts (Gilman et al., 2011) or synaptic transmission (Li et al., 2014). The majority o

• A high throughput small molecule ACK biochemical

  2024-02-02

  

  A high-throughput small molecule ACK1 biochemical inhibition screen was performed in-house and led to the identification of 1μM inhibitor furanopyrimidine (). Further binding studies found SU5416 to be both ATP-competitive and reversible. Early structure-activity relationship (SAR) work was perfo

• With the treatment options available today including a combi

  2024-02-02

  

  With the treatment options available today including a combination of symptomatic treatments and general immunosuppression, many MG patients can lead productive lives [1], [4], [20]. The frequency of death has decreased due to improved management and detection of milder cases. At present, the overal

• br Experimental section br Results and discussion br Conclus

  2024-02-02

  

  Experimental section Results and discussion Conclusion Acknowledgements This work was financially supported by Recruitment Program of Global Experts, and the Director Foundation of XTIPC, CAS, Grant No. 2015RC011. This work was also financially supported by Natural Science Foundation of

• po1 mg We conducted the largest drug screen to date

  2024-02-02

  

  We conducted the largest drug screen to date in HPV-positive cancers and identified Aurora kinase inhibitors as effective and understudied drugs in HNSCC and CESC. These drugs cause apoptosis and cell cycle arrest in vitro and decrease tumor size in vivo. This is the first published study to demonst

• Herbal medicines have been used to treat various types of

  2024-02-02

  

  Herbal medicines have been used to treat various types of diseases and disorders for thousands of years worldwide (Li and Brown, 2009). Natural products have been the remedy of cancer chemotherapy for the past several decades. Anisomeles indica (L.) Kuntze. (Labiatae), commonly known as 'yu-chen-tsa

• To introduce in a simple way the variability

  2024-02-02

  

  To introduce in a simple way the variability in the concentration of the proteins involved in the process, and to consider possible stochastic effects due to possible finite sizes of the populations involved in the problem, the dynamics of each cell is studied using the Gillespie’s algorithm (Gilles

• Prostate cell growth and prostate carcinogenesis are not

  2024-02-01

  

  Prostate cell growth and prostate carcinogenesis are not only mediated by androgens, they are also dependent on functional insulin receptor (IR) and insulin-like growth factor-1 (IGF-1) receptor (IGF1R) signaling. Previous studies addressed this issue and reported a correlation between high insulin

• As noted above yeasts particularly S

  2024-02-01

  

  As noted above, yeasts, particularly S. cerevisiae (Frey and Röhm 1978; Trumbly and Bradley 1983), produce APs, but these are intracellular enzymes located in the vacuolar compartment, with the exception of aminopeptidase II. About 40% of aminopeptidase II activity is detected as external enzyme, li

• Various compounds have been designed to inhibit aldose reduc

  2024-02-01

  

  Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic 4-iodo-SAHA moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to be a p

• br Materials and methods br

  2024-02-01

  

  Materials and methods Results and discussion First, we examined whether hypothalamic Akt-mediated signaling pathways are regulated postprandially in chickens. Refeeding significantly (P Voreloxin Hydrochloride receptor concentrations significantly increased in chicks after 1 h of refeeding (95

• Blockers will reduce perioperative myocardial ischemia and

  2024-02-01

  

  β-Blockers will reduce perioperative myocardial ischemia and studies published in the 1990s suggested that their routine administration before surgery provided protection against perioperative CV complications.31., 32., 33. Based on these early studies, several national organizations endorsed the pe

15061 records 150/1005 page Previous Next First page 上5页 146147148149150 下5页 Last page